-globin gene families
نویسندگان
چکیده
Gabriela Aguileta *, Joseph P. Bielawski 3,4 and Ziheng Yang 1 1 Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, England 2 Linnaeus Centre for Bioinformatics, University of Uppsala, BMC, Box 598, 75124, Uppsala, Sweden 3 Department of Biology, Dalhousie University, Halifax, Nova Scotia, B3H 4J1, Canada 4 Department of Mathematics & Statistics, Dalhousie University, Halifax, Nova Scotia, B3H 4J1, Canada
منابع مشابه
Co-inheritance of α-and β-thalassemia: challenges in prenatal diagnosis of thalassemia
Background: The double heterozygous state of α/β thalassemia may alter the hematological indices and modify the phonotype. In addion, definite characterizaon of co-inheritance of α- and β-thalassemia heterozygous carriers may change the process of genec counseling. Materials and Methods: An Iranian couple with low hematological indices was analyzed for α-globin gene deleons using mulpl...
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Background: β-thalassemia is one of the most widespread disease in the world, including Iran. In this study, we reported, for the first time, A 290-bp β-globin gene deletion in the south of Iran. Methods: Four individuals from three unrelated families with Arabic ethnic background were studied in Khuzestan Province. Red blood cell indices and hemoglobin analysis were carried out accor...
متن کاملGene Turnover in the Avian Globin Gene Families and Evolutionary Changes in Hemoglobin Isoform Expression
The apparent stasis in the evolution of avian chromosomes suggests that birds may have experienced relatively low rates of gene gain and loss in multigene families. To investigate this possibility and to explore the phenotypic consequences of variation in gene copy number, we examined evolutionary changes in the families of genes that encode the α- and β-type subunits of hemoglobin (Hb), the te...
متن کاملLineage-specific patterns of functional diversification in the alpha- and beta-globin gene families of tetrapod vertebrates.
The alpha- and beta-globin gene families of jawed vertebrates have diversified with respect to both gene function and the developmental timing of gene expression. Phylogenetic reconstructions of globin gene family evolution have provided suggestive evidence that the developmental regulation of hemoglobin synthesis has evolved independently in multiple vertebrate lineages. For example, the embry...
متن کاملLineage-Specific Patterns of Functional Diversification in the α- and β-Globin Gene Families of Tetrapod Vertebrates
The αand β-globin gene families of jawed vertebrates have diversified with respect to both gene function and the developmental timing of gene expression. Phylogenetic reconstructions of globin gene family evolution have provided suggestive evidence that the developmental regulation of hemoglobin synthesis has evolved independently in multiple vertebrate lineages. For example, the embryonic β-li...
متن کاملGene Turnover and Diversification of the α- and β-Globin Gene Families in Sauropsid Vertebrates
The genes that encode the α- and β-chain subunits of vertebrate hemoglobin have served as a model system for elucidating general principles of gene family evolution, but little is known about patterns of evolution in amniotes other than mammals and birds. Here, we report a comparative genomic analysis of the α- and β-globin gene clusters in sauropsids (archosaurs and nonavian reptiles). The obj...
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